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}
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É só genética? Ambiente influencia sexo dos camundongos, diz estudo 37173i
Tecnologia 5cw3f É só genética? Ambiente influencia sexo dos camundongos, diz estudo 37173i Publicado
2 dias ago on
06/06/2025
Estudo com camundongos mostrou que a deficiência de ferro na gestação pode causar alteração no sexo biológico
(Reprodução: Nikolett Emmert/Unsplash) Pesquisadores da Universidade de Osaka, no Japão, descobriram que a deficiência de ferro durante a gestação pode interferir na formação dos órgãos sexuais de camundongos ainda não nascidos, desafiando a ideia tradicional de que o sexo é determinado apenas por fatores genéticos.
As descobertas foram publicadas na revista Nature
Descoberta inédita desafia a ideia de que o sexo é determinado apenas pelos genes (Imagem: Gallinago_media/Shutterstock) Descobertas do estudo 584y38 O estudo mostrou que camundongos com cromossomos XY (geneticamente machos) desenvolveram ovários ou órgãos sexuais mistos quando suas mães foram privadas de ferro no período crítico da determinação do sexo fetal. A explicação está na enzima KDM3A, que ativa o gene Sry, localizado no cromossomo Y, essencial para o desenvolvimento dos testículos. A atividade da KDM3A, no entanto, depende do ferro para funcionar corretamente. Pesquisa japonesa sugere que fatores ambientais podem influenciar o desenvolvimento sexual além da genética (Imagem: Natali _ Mis/Shutterstock.com) Dietas especiais foram aplicadas 215551 Os experimentos incluíram a istração de medicamentos que removem ferro e dietas com baixo teor do nutriente. Em ambos os casos, uma pequena porcentagem dos camundongos machos apresentou alterações no desenvolvimento sexual.
Os efeitos só foram observados quando havia também uma mutação no gene da KDM3A ou deficiência severa de ferro, sugerindo uma interação complexa entre genética e ambiente.
Embora os resultados ainda não permitam conclusões definitivas, os cientistas acreditam que o estudo abre caminho para investigações mais amplas sobre como fatores nutricionais podem influenciar a expressão genética.
Camundongos machos nasceram com ovários após mães receberem dieta pobre em ferro (Imagem: Aleksandr Pobeda/Shutterstock)
Colaboração para o Olhar Digital
Leandro Criscuolo é jornalista formado pela Faculdade Cásper Líbero. Já atuou como copywriter, analista de marketing digital e gestor de redes sociais. Atualmente, escreve para o Olhar Digital.
Bruno Capozzi é jornalista formado pela Faculdade Cásper Líbero e mestre em Ciências Sociais pela PUC-SP, tendo como foco a pesquisa de redes sociais e tecnologia.
OLHAR DIGITAL – Link original da matéria
